ASUS
SKU: PRIME-RTX5080-O16G
Overview
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Overview
Questions about this product? Free pre-sales support from a senior specialist — product questions, compatibility checks, BOM quotes, price confirmation — typically answered within one business day. Need camera placement or system design work? Engineering time is $175 per hour (qty 1 = 1 hour). Hardware buyers get up to one hour ($175) credited back on their order.
The ASUS RTX5080-O16G-NOCTUA pairs NVIDIA's GeForce RTX 5080 GPU with a purpose-built Noctua cooling solution — a combination that targets workstation operators and compute-intensive deployments where sustained thermal performance and acoustic discipline matter as much as raw throughput. With 10,752 CUDA cores, 16GB of GDDR7 memory on a 256-bit bus, and a factory-overclocked boost clock of 2,730 MHz in OC mode, this card is positioned for AI inference workloads, real-time video analytics, and professional visualization tasks that would saturate a mid-range GPU in minutes. At 20.55 × 10.35 × 4.94 inches and 7.74 lb, this is a physically substantial card — confirm your chassis clearance before ordering.
The RTX5080-O16G-NOCTUA connects via PCI Express 5.0, making it compatible with current-generation Intel and AMD platforms supporting PCIe 5.0 x16 slots. It will operate on PCIe 4.0 and 3.0 systems at negotiated speeds — confirm your platform's mechanical slot length (x16 physical) and power delivery capacity before deployment. The card requires a motherboard slot capable of supporting its weight and length; use GPU support brackets in horizontally-oriented builds.
For graphics cards deployed in AI inference or video analytics roles, pair with a platform offering sufficient system memory bandwidth and NVMe storage to avoid upstream bottlenecks. The five display outputs make this suitable as the sole display adapter in a professional workstation driving multi-monitor analyst setups. For builds requiring multiple high-bandwidth peripherals, review your platform's PCIe lane allocation — a CPU with 24+ PCIe lanes avoids contention between the GPU, NVMe drives, and any capture or network cards.
Power supply requirements scale with the RTX 5080's TDP — size your PSU to the card's published power specification with a margin for system load. Use high-quality PCIe power cables rated for the connector type the card specifies; do not use daisy-chained connectors from a single PSU rail for this class of card. For deployment planning support, ASUS GPU configurations are available with pre-sales guidance. Also consider workstation cooling accessories to complement the Noctua thermal solution at the case level, and review GPU selection guidance for workload-matching advice.
Q: What are the physical dimensions of the RTX5080-O16G-NOCTUA, and will it fit in a standard mid-tower case?
A: The card measures 20.55 inches long × 10.35 inches wide × 4.94 inches tall (L × W × H) and weighs 7.74 lb. Most standard mid-tower cases top out at 14–16 inches of GPU clearance — this card requires a large mid-tower or full-tower chassis. Measure your case's GPU length clearance before ordering.
Q: How many monitors can the RTX5080-O16G-NOCTUA drive simultaneously, and at what resolutions?
A: The card supports up to four simultaneous displays using any combination of its five outputs (2× HDMI 2.1b, 3× DisplayPort 2.1b). Maximum resolution is 7680×4320 (8K). HDMI 2.1b supports up to 4K/144Hz or 8K/60Hz; DisplayPort 2.1b supports up to 4K/240Hz or 8K/60Hz depending on display capability.
Q: What is the difference between OC mode and standard mode on the RTX5080-O16G-NOCTUA?
A: In OC mode the GPU boost clock runs at 2,730 MHz versus 2,700 MHz in standard mode. The Dual BIOS feature lets you switch between these profiles via a physical switch on the card — no software required. OC mode delivers slightly higher peak performance; standard mode runs marginally cooler and quieter under sustained load.
Q: Does the 0dB technology on the RTX5080-O16G-NOCTUA mean the fans never spin?
A: No — 0dB technology means the three Noctua NF-A12x25 G2 fans stop completely at idle and under light load, eliminating fan noise when the GPU is not under compute stress. The fans spin up automatically as GPU temperature rises during active workloads. You will hear the fans during sustained GPU-intensive tasks.
Q: What PCIe slot does the RTX5080-O16G-NOCTUA require?
A: The card uses a PCI Express 5.0 interface and requires a physical x16 PCIe slot. It is backward compatible with PCIe 4.0 and 3.0 x16 slots at negotiated bandwidth. For full PCIe 5.0 throughput, install into a PCIe 5.0 x16 slot on a compatible current-generation motherboard.
Q: Is the RTX5080-O16G-NOCTUA suitable for AI inference and video analytics workloads?
A: The 10,752 CUDA cores and 16GB of GDDR7 memory make it capable for AI inference tasks and real-time video analytics pipelines. Suitability for a specific workload depends on the software framework, model size, and throughput requirements — verify against your application's published GPU compatibility list before deploying in a production environment.

The RTX5080-O16G-NOCTUA is one of those cards I recommend when the workload is real and the environment doesn't tolerate fan noise. The combination of 10,752 CUDA cores with 16GB of GDDR7 at 30 Gbit/s gives you genuine headroom for AI inference and multi-stream video analytics — and the three Noctua NF-A12x25 G2 PWM fans mean you can sustain those loads without the GPU becoming the loudest thing in the room.
Technical Highlights:
Deployment Considerations:
This card fits best in a dedicated AI inference workstation or a command-center build where an operator runs four high-resolution displays and analytics software simultaneously — the memory capacity, CUDA throughput, and acoustic profile all line up for that scenario.
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