HPE P50312-B21 64GB DDR5 ECC RDIMM Server Memory Kit

Overview

The P50312-B21 is a 64GB DDR5-4800 registered ECC DIMM kit designed for HPE ProLiant Gen11 and Apollo Gen11 AMD platforms. A single 288-pin RDIMM running at 4800 MT/s (PC5-38400) with CL42 latency, it targets memory-intensive server workloads — database instances, virtualization hosts, and AI inference nodes — where density per slot and data integrity matter. ECC (Error Correcting Code) support catches and corrects single-bit memory errors in real time, which is non-negotiable in always-on server environments where a silent memory fault can corrupt live data or crash a VM.

Compatibility

Qualified for HPE ProLiant Gen11 servers and the Apollo family Gen11 AMD configurations. HPE Smart Memory designation means the module communicates with HPE's Advanced Memory Protection and memory mirroring subsystems — capabilities that only activate with qualified Smart Memory modules, not generic DDR5 DIMMs. Before installing, verify your specific ProLiant model's memory population rules in the HPE QuickSpecs for that server — Gen11 platforms enforce population order and mixed-rank constraints that affect maximum achievable bandwidth. This kit ships as a single 64GB module (2Rx4 dual-rank x4 organization), so pairing with an identical module in the correct slot sequence is required to enable dual-channel operation.

Installation Notes

Handle the RDIMM by its edges only — DDR5 modules are sensitive to static discharge. Seat firmly until both retention clips lock. Confirm BIOS/UEFI detects the module at full 4800 MT/s; some Gen11 configurations may train at a lower speed if population rules are violated. Weight is 0.20 lb; physical dimensions are 1.00 in (height) × 6.75 in (depth), consistent with standard 288-pin RDIMM form factor.