HPE P43331-B21 64GB DDR5-4800 ECC Registered Smart Memory Kit

Overview

The P43331-B21 is a 64GB DDR5 RDIMM designed for HPE ProLiant Gen11 and Apollo Gen11 AMD server platforms. As a single 288-pin RDIMM module running at 4800 MT/s (PC5-38400), it delivers double the per-DIMM density of a typical 32GB slot fill — useful when expanding memory capacity in servers with limited DIMM slots or when consolidating workloads onto fewer physical nodes. ECC (Error Correcting Code) data integrity protection is built in, a non-negotiable requirement for production server environments where silent data corruption is not acceptable. The CL42 latency rating is standard for DDR5-4800 server-class DIMMs at this density. This is a factory-new, genuine HPE Smart Kit — HPE Smart Memory kits are validated against HPE firmware and BIOS, which matters for ProLiant servers that actively interrogate DIMM SPD data at POST; non-validated DIMMs can trigger speed downgrade or compatibility warnings in iLO.

Compatibility

Validated for HPE ProLiant Gen11 server platforms and the Apollo Gen11 AMD family. This includes ProLiant DL, ML, and BL Gen11 AMD-based systems that specify PC5-4800B-R registered DDR5 support. Before installing, confirm your specific ProLiant model's memory configuration guide — Gen11 Intel-based systems use a different DDR5 speed bin and DIMM topology and are not covered by this part number. Mixed-rank or mixed-speed DIMM configurations on Gen11 platforms may trigger memory speed reduction; populating channels symmetrically with matched DIMMs delivers the rated 4800 MT/s throughput. The 2Rx4 rank configuration indicates a dual-rank, x4 device organization — check your platform's rank mixing rules if pairing with existing DIMMs.

Installation Notes

Module weight is 0.20 lb; handle by edges to avoid ESD damage to DDR5 signal traces. Shipping dimensions indicate standard RDIMM form factor (288-pin, full-length). Seat firmly until both DIMM slot retaining clips latch — partial seating is a common cause of POST memory errors on HPE ProLiant platforms. After installation, verify detection and operating speed in HPE iLO System Information before returning the system to production.